Error 0x80070780: The file cannot be accessed by the system
Background
I’ve had a load of problems with file access after reinstalling Windows Server 2012 R2 after system disk crash on my private storage server. The server uses Storage Spaces to manage my 6 disks and the disk cluster consists of a single 7TB volume in RAID10 mode for maximum performance (and hopefully reliabilty).
Solution
Make sure all the services and roles of the old server has been installed. In this case I was missing the “Data Deduplication” service.
A big thanks to JonReeves for answering his own problem at the TechNet forums after troubleshooting.